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MIF has a novel marriage with glucocorticoids as MIF can be secreted from corticotropic anterior pituitary cells along with ACTH that can encourage adrenal glucocorticoid secretion. As proven in determine four, less than pressure and inflammation ailments, MIF is induced by glucocorticoids but functions being an antagonist of glucocorticoid steps w
To date, the precise binding website of MIF to CD74 is not really obvious, but modest molecules and mutations concentrating on the tautomerase Lively site pocket are actually revealed to interfere with the binding of MIF to CD74 [44]. Apparently, Fan et al. generated a single cysteine mutant of MIF (MIFN110C) that covalently locks MIF into a trimer